A. In our experience, the average stem cell therapy ranges between $3,500 and $7,000. Although this may seem like a lot of money, the majority of the time the cost is less than your out of pocket expenses for more traditional therapies. For example, the average total knee replacement costs $50,000 and the client’s responsibility is 20% which is $10,000. And, this does not include the time off work for recovery. In the end, stem cell therapy is a less expensive option for regenerative wellness.